A guitar is sound like any other sound. Photism does not care if it came from a synth, a drum bus, or a Stratocaster, so none of the setup below needs Ableton, a DAW, or a plugin host. If you already own an interface or a modeler, you likely have everything required.
Plug in directly
If your interface has a 1/4“ instrument input (often labeled Hi-Z), that is a straight line in. No DI box required for most passive pickups.
A lot of players already have a shortcut: amp modelers and multi-effects units with a USB output (Line 6 Helix, Boss GT and ME-series, Fractal, and others) act as a class-compliant audio interface the moment you plug the USB cable into a laptop. There is no separate interface to buy.
Either way, open photism.app/online, click SOURCE, and pick the interface or modeler from the list. Play, and the scene reacts to whatever comes out after your amp sim and effects chain, so distortion, delay, and reverb all show up in what the visuals see.
Mic the amp instead
Running a real amp instead of a modeler works the same way. Put a mic on the cab, the same one you would use to record it, into your interface, and pick that channel as the source.
Looper rigs
Building loops live (an RC-series or Ditto pedal, or Ableton’s own Looper device) stacks layers of sound one on top of another. Photism hears the same buildup your amp does. Each new layer raises the total energy in the signal, which is what drives a scene’s structural changes, so a loop that keeps building reads as a build in the visuals too, without any manual cueing.
Getting it on a screen
shift+o opens a separate output window. Drag it to a second display,
projector, or TV and fullscreen it. For a small room or busking, the
laptop screen turned toward the crowd works fine on its own.
Try it before you install
The whole setup runs free in a browser at photism.app/online. Plug in, set the source, and play a few bars to see the response.